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What is an Estradiol Test and Why is it Used?

An estradiol test is a simple blood test to measure the amount of estradiol in a person’s blood. Estradiol, also known as E2, is one of the four types of estrogen that the ovaries chiefly produce. The adrenal glands, placenta, testes, and some tissues also produce smaller amounts of this hormone.
The right estrogen levels are essential for reproductive health. Having too much or too little estrogen can also lead to medical problems, such as weak bones, urinary tract infections, and even depression.

Doctors may order an estradiol test if they are concerned about a person’s fertility, puberty, or menopause. In this article, we examine when a doctor might order this test, what the results can mean, and what to expect during and after the test.

Why might it be used?

Doctors will likely request an estradiol test if they want to find out more about why a person’s sex characteristics are developing in a certain way.

Although estrogen is known as a female sex hormone, it also plays a role in male growth and development.

Estradiol levels can affect how the reproductive system develops. Abnormally high or low levels can influence how the following parts of the body grow and work:

During their reproductive years, women usually have their highest levels of estradiol. After reaching menopause, estradiol levels are much lower.

Problems caused by abnormal levels of estradiol include:

Transgender women may take estradiol as part of their hormone therapy to develop more female characteristics. If so, their doctor may wish to perform regular estradiol tests to monitor their levels.

Learn more about the possible causes behind low estrogen levels here, along with their effects on the body and treatment options.

Possible risks

An estradiol test is a simple blood test, and its risks are low. However, any test involving a needle carries some risks, such as:


While some blood tests require a person to avoid eating or drinking beforehand, people taking an estradiol test do not need to make any special preparation.

If a person is taking any medication, such as birth control or hormone therapy medication, they must tell their doctor before they have the test. Certain forms of medication could affect the results.


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Source: Medical News Today