A New Role for ApoE Explains its Diverse Range of Effects, Particularly in Alzheimer’s

A New Role for ApoE Explains its Diverse Range of Effects, Particularly in Alzheimer’s

A study from the Buck Institute and UCLA offers an explanation for why a particular genetic form (allele) of apolipoprotein E (ApoE) poses the most significant genetic risk for Alzheimer’s disease. Publishing on January 20th in The Journal of Neuroscience, researchers cast the lipid-binding ApoE4 in an entirely new light, showing that it is a transcription factor that enters the nucleus and binds DNA with high affinity, including the promoter regions of 1700 different genes. Seventy-five million Americans are ApoE4 carriers, putting them at increased risk for Alzheimer’s disease, and another 7 million carry two copies of ApoE4, giving them an even higher, 10 — 12 fold increased risk of developing Alzheimer’s… Read More>>

Source: ScienceDaily

Send this to a friend