Merck stopping late stage study as another Alzheimer’s drug fails
Merck & Co Inc said on Tuesday it will halt a late-stage trial of an Alzheimer’s drug after it was determined that it had no chance of working, marking the latest in a long line of crushing disappointments in efforts to find an effective treatment for the mind-wasting disease.
The company was testing its drug, verubecestat, in patients with mild to moderate Alzheimer’s disease. But an independent data monitoring committee determined that there was “virtually no chance of finding a positive clinical effect” and recommended the trial be stopped for futility.
The news sent Merck shares down nearly 2 percent in after hours trading.
Verubecestat belongs to a class of experimental Alzheimer’s drugs called BACE1 inhibitors that target an enzyme involved in the formation of the toxic amyloid protein that turns into plaques in the brains of Alzheimer’s patients.
Several companies are pinning hopes on Alzheimer’s treatments using the BASE inhibitor mechanism, including Eli Lilly and Co, Biogen and Novartis in collaboration with Amgen Inc.
Lilly previously endured multiple failures with its solanezumab, which also targets beta amyloid, but in a different way. In the most recent setback, Lilly said that drug failed to slow declines in mental capacity of patients with even mild symptoms.
Researchers are increasingly focusing on attacking the disease earlier as it appears likely that once symptoms have taken hold current approaches fail to work… Read More>>