Topic Summary
Obesity is a major driver of HFpEF, creating diagnostic pitfalls and high morbidity. In this article, Cardiologist Prof Andrew Sindone AM reviews obesity–HFpEF pathophysiology, sex-specific risks, and how low natriuretic peptides complicate diagnosis. He outlines practical, evidence based management to improve symptoms, reduce hospitalisations, and potentially reverse disease.
Featured Expert

Prof Andrew Sindone AM
Cardiologist; Director of the Heart Failure Unit and Department of Cardiac Rehabilitation, Concord Hospital; Head, Department of Cardiology, Ryde Hospital
Learning Objectives
- Identify obesity’s central role in HFpEF and female predominance
- Assess symptoms, biomarkers, and imaging to confirm suspected HFpEF
- Implement multimodal therapy: lifestyle, SGLT2, MRAs, and incretin agents
CPD and Accreditation
This activity is accredited with the RACGP and ACRRM for the following hours:
- 0.5 hours in the Educational Activities (EA)
- 0.5 hours Reviewing Performance (RP)
- 1 hour Measuring Outcomes (MO)
You can track your Healthed learning and download a CPD Statement as evidence of completion, which may support self‑claimed professional development with your professional body.
If you are a member of the RACGP or ACRRM, Healthed will upload CPD hours on your behalf within four (4) weeks of the activity’s completion.

Disclosure Statement
Proudly supported by an independent educational grant from Lilly. April 2026




