Rethinking HFpEF: Targeting obesity as the root cause

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Topic Summary

Obesity is a major driver of HFpEF, creating diagnostic pitfalls and high morbidity. In this article, Cardiologist Prof Andrew Sindone AM reviews obesity–HFpEF pathophysiology, sex-specific risks, and how low natriuretic peptides complicate diagnosis. He outlines practical, evidence based management to improve symptoms, reduce hospitalisations, and potentially reverse disease.

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Learning Objectives
  • Identify obesity’s central role in HFpEF and female predominance
  • Assess symptoms, biomarkers, and imaging to confirm suspected HFpEF
  • Implement multimodal therapy: lifestyle, SGLT2, MRAs, and incretin agents
CPD and Accreditation

This activity is accredited with the RACGP and ACRRM for the following hours:

  • 0.5 hours in the Educational Activities (EA)
  • 0.5 hours Reviewing Performance (RP)
  • 1 hour Measuring Outcomes (MO)

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If you are a member of the RACGP or ACRRM, Healthed will upload CPD hours on your behalf within four (4) weeks of the activity’s completion.

Disclosure Statement

Proudly supported by an independent educational grant from Lilly. April 2026

Module Content

Summary – Rethinking HFpEF: Targeting obesity as the root cause