In this Healthed lecture, A/Prof Dion Forstner & Dr Farshad Kasraei explain that radiation therapy is the most effective non-invasive option for keratinocyte cancer lesions, with 5-year control rates approaching surgery. It also complements surgery well in the adjuvant setting for high-risk disease. Advances in technology and an understanding of radiobiological processes has allowed it to be applied to a wider variety of disease presentations, whilst mitigating acute and chronic side effects.