John Worthington

Experts / John Worthington

Senior Lecturer in Infection Biology, Lancaster University

The intestinal epithelium offers the first interaction between commensal bacteria, pathogens and our bodies’ largest immune system. Inappropriate immune responses drive inflammatory bowel disease (IBD) or excessive inflammation during infection. My research focuses on the epithelial enteroendocrine cells (EECs), which release peptide hormones in response to nutrients allowing their efficient digestion. EEC alterations are strongly associated with inflammation, yet the possibility of interactions between our gut’s endocrine and immune systems remains overlooked. Understanding the mechanistic cross-talk between enteroendocrine and immune cells will identify the immunoendocrine axis as a key feature of intestinal health which could be therapeutically targeted during disease.

Tapeworm in bacon-lover’s brain presents as migraine

A middle-aged man from Florida with a history of migraines saw his GP. After the CT scan, something alarming was revealed: his brain was infested with tapeworm cysts...

Tapeworm in bacon-lover’s brain presents as migraine

A middle-aged man from Florida with a history of migraines saw his GP. After the CT scan, something alarming was revealed: his brain was infested with tapeworm cysts...

By John Worthington

Clinical Articles

Infectious diseases