PPIs in children – an asthma risk
The recent push-back against adult use of PPIs looks like it should include children with research showing they pose a significant asthma risk in the paediatric population.
According to a Swedish cohort study recently published in JAMA Pediatrics (1), children who are initiated on a proton pump inhibitor have a 57% increased risk of developing asthma.
Using one of those enviable Scandinavian databases researchers were able to compare over 80, 000 children who had been treated with a PPI with a similar number of matched controls who had not used the acid-suppressing medication. Their primary analysis looked at the risk of incident asthma with a median follow-up of three years
“An increased risk was observed across ...