Recommended diuretic causes more side effects than similar hypertension drug
Due to it’s perceived greater efficacy and the greater body of evidence supporting its use, chlorothalidone is preferred over hydrochlorothiazide for treatment of hypertension. A new study, recently published in JAMA Internal Medicine, may have cast this guideline into doubt.
The study, led by researchers at Columbia University Irving Medical Center, found that the two diuretics were similarly effective at preventing stroke, hospitalisation from heart failure and heart attack. It also found that patients treated with chlorthalidone had a significantly higher risk of a range of potentially dangerous side effects.
The greatest difference found was a nearly three times greater ...