GLP-1 and GLP-1/GIP RAs for obstructive sleep apnoea – What is their role?

Prof Brendon Yee

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Prof Brendon Yee

Respiratory and Sleep Medicine Physician; Woolcock Institute of Medical Research; Staff Specialist and Medical Director of Respiratory Failure Services, Royal Prince Alfred Hospital; Consultant, Rural Outreach Services

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Prof Brendon Yee

How new evidence will change how we assess and manage OSA

With obesity demonstrating mortality rates comparable to cigarette smoking, and obstructive sleep apnoea (OSA) potentially affecting up to one billion people worldwide, the intersection of these conditions demands innovative therapeutic approaches.

Recent advances in incretin-based therapies, particularly the GLP-1/GIP receptor agonist tirzepatide (Mounjaro), are revolutionising treatment for patients with concurrent obesity and OSA, offering clinically significant improvements that may challenge traditional CPAP-centric management strategies.

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References

  1. Benjafield AV, et al. Lancet Respir Med. 2019;7(8):687–98.
  2. Nieto FJ, et al. 2000;283(14):1829–36.
  3. Hedner J, et al. Eur Respir J. 2011;38(2):434–42.
  4. Peppard PE, et al. 2000;284(23):3015–21.
  5. Malhotra A, et al. Sleep Med. 2024;121:11.
  6. Davies MJ, et al. Diabetes Care. 2016;39(11):1972–80.
  7. Wilding JPH, et al. N Engl J Med. 2021;384(11):989–1002.
  8. Malhotra A, et al. N Engl J Med. 2024;391(15):1464–75.
  9. Azarbarzin A, et al. Eur Heart J. 2019;40(14):1149–57.
  10. Bratton DJ, et al. 2015;314(21):2280–93.
  11. Jastreboff AM, et al. N Engl J Med. 2025;392:958–71.
  12. Aronne LJ, et al. 2024;331(1):38–48.
  13. Jastreboff AM, et al. N Engl J Med. 2023;389:514–26.
  14. Gabryelska A, et al. J Clin Med. 2022;11(1):139.
  15. Javaheri S, et al. Chest. 2019;156(3):321–30.
  16. Abushamat LA, et al. Curr Cardiol Rep. 2024;26(7):739–47.
  17. Rubino F, et al. Nat Rev Endocrinol. 2020;16(12):715–16.
  18. Zhang Y, et al. Diabetes Obes Metab. 2023;25(11):2915–27.
  19. Loomba R, et al. N Engl J Med. 2023;389(4):336–49.
  20. Packer M, et al. N Engl J Med. 2023;389(12):1085–95.
  21. Siniukovich A, et al. Diabetol Metab Syndr. 2025;17:247.
  22. Bliddal H, et al. N Engl J Med. 2024;391(15):1464–75.
  23. Leggio L, et al. N Engl J Med. 2023;389(15):1399–409.
  24. Douros A, et al. Lancet Diabetes Endocrinol. 2024;12(5):327–36.
  25. Samms RJ et al. Trends in Endocrinology & Metabolism, 31 (6), 2020, 410-421.

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Prof Brendon Yee

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Prof Brendon Yee

Respiratory and Sleep Medicine Physician; Woolcock Institute of Medical Research; Staff Specialist and Medical Director of Respiratory Failure Services, Royal Prince Alfred Hospital; Consultant, Rural Outreach Services

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