Pharmacogenomics coming to general practice
Pharmacogenomics is the study of genetic differences that affect an individual’s medication response and metabolism1.
Genetic variation in these processes can cause a patient to have an unexpected exposure to a medication, such as
- unexpectedly low or high blood concentrations (despite the patient having the recommended dose)
- unexpected lack of or excessive response to a medication (despite the blood concentration being normal)
- severe acute reaction e.g. skin rash, hepatitis (despite the medication typically being well-tolerated).
By knowing the variations in a patient’s genes, the prescriber can select a medication and dose that ...