Pharmacogenomics coming to general practice

Pharmacogenomics coming to general practice

Pharmacogenomics is the study of genetic differences that affect an individual’s medication response and metabolism1.

Genetic variation in these processes can cause a patient to have an unexpected exposure to a medication, such as

  • unexpectedly low or high blood concentrations (despite the patient having the recommended dose)
  • unexpected lack of or excessive response to a medication (despite the blood concentration being normal)
  • severe acute reaction e.g. skin rash, hepatitis (despite the medication typically being well-tolerated).

By knowing the variations in a patient’s genes, the prescriber can select a medication and dose that ...

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