How to manage patients who have reached their weight loss goal on GLP-1 based medications

Dr Paige Lanyon-Roberts

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Dr Paige Lanyon-Roberts

General Practitioner, Bariatric Doctor & Surgical Assistant; Medical Director, MedSurg Weight Loss

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Patients taking medications for weight loss often ask if they will ever be able to stop or reduce their dose without sacrificing results – but until now, there has not been randomised controlled data to inform the answers.

However, in May, the Lancet published results from SURMOUNT-MAINTAIN1, the first randomised controlled trial to examine whether patients can maintain weight loss and cardiometabolic benefits at a lower dose of an effective obesity medication.

This article summarises the key findings and offers practical guidance on how Australian GPs can apply this evidence in clinical consultations.

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References

  1. Horn D et al. Lancet. 2026;407:2305–2318.
  2. Aronne LJ et al. JAMA. 2024;331(1):38–48.
  3. Rubino D et al. JAMA. 2021;325(14):1414–25.
  4. West S et al. BMJ. 2026;392:e085304.
  5. Jastreboff AM, et al. N Engl J Med. 2022;387:205–216.
  6. Wilding JPH et al. N Engl J Med. 2021;384:989–1002.
  7. Gilbert O et al. J Am Coll Cardiol. 2025;86(7).

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