Tirzepatide vs semaglutide: A head-to-head comparison for management of obesity

A/Prof Samantha Hocking

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A/Prof Samantha Hocking

Endocrinologist; Royal Prince Alfred Hospital; Clinical Academic at Charles Perkins Research Centre, University of Sydney; President, National Association of Clinical Obesity Services (NACOS)

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The SURMOUNT-5 trial has provided definitive evidence that tirzepatide is superior to semaglutide for obesity treatment, achieving an additional 6.5% body weight reduction and nearly doubling the proportion of patients who lose 25% or more of their body weight.

This landmark head-to-head comparison, recently presented at the European Congress of Obesity in Spain, represents the first direct evidence comparing these two leading obesity medications helping to guide optimal treatment selection.

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References

N Engl J Med 2021;384:989-1002 (STEP 1)
N Engl J Med 2022;387:205-216 (SURMOUNT-1)
N Engl J Med 2025;393:26-36 (SURMOUNT-5)

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A/Prof Samantha Hocking

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A/Prof Samantha Hocking

Endocrinologist; Royal Prince Alfred Hospital; Clinical Academic at Charles Perkins Research Centre, University of Sydney; President, National Association of Clinical Obesity Services (NACOS)

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