Investigation of Paraproteinaemia

Dr Daman Langguth

writer

Dr Daman Langguth

Head of the Immunology Department at Sullivan Nicolaides Pathology; Chair of Sullivan Nicolaides Pathology Partners.

Dr Daman Langguth

Paraproteins are abnormal monoclonal immunoglobulins produced in plasma cell disorders (eg multiple myeloma), lymphoproliferative disorders (eg CLL, Waldenstrom’s macroglobulinaemia) and in some infections (hepatitis C).

The introduction of the assay, serum free light chains (FLC) has meant the initial investigation of paraproteinaemia has become much simpler.

Previously, serum tests had great difficulty in detecting immunoglobulin light chains for two reasons:

1. Light chains are rapidly cleared by the kidneys, up until a certain point where they ‘spilled’ over into the blood.
2. Assays had poor sensitivity in detecting ‘free’ light chains ie light chains not bound to heavy chains as in normal immunoglobulin.

PASSWORD RESET

Forgot your password or password not working? Please enter your email address. You will receive an email with the link to set a new password.

Icon 2

NEXT LIVE Webcast

:
Days
:
Hours
:
Minutes
Seconds
A/Prof Nicole Goh

A/Prof Nicole Goh

The NLCSP – Incidental Chest Findings – What Now? – A Focus on Interstitial Lung Abnormalities

A/Prof Mark Yates

A/Prof Mark Yates

Dementia & Chronic Disease – Practical Advice

Dr Julia Crawford

Dr Julia Crawford

Head and Neck Lumps

A/Prof Martin MacDonald

A/Prof Martin MacDonald

Why are LAMAs Useful in Asthma Management

Join us for the next free webcast for GPs and healthcare professionals

High quality lectures delivered by leading independent experts

Share this

Share this

Dr Daman Langguth

writer

Dr Daman Langguth

Head of the Immunology Department at Sullivan Nicolaides Pathology; Chair of Sullivan Nicolaides Pathology Partners.

Test your knowledge

Recent articles

Latest GP poll

AHPRA's new CEO says he is committed to improving how complaints are handled. How likely is this to succeed?

Likely to succeed

0%

Unlikely to succeed

0%

Find your area of interest

Once you confirm you’ve read this article you can complete a Patient Case Review to earn 0.5 hours CPD in the Reviewing Performance (RP) category.

Select ‘Confirm & learn‘ when you have read this article in its entirety and you will be taken to begin your Patient Case Review.

Upcoming Healthed Webcast

Tuesday 16th September, 7pm - 9pm AEST

Speaker

A/Prof Mark Yates

Director of Clinical Studies, Ballarat Clinical School at Deakin University

We invite you to our next free webcast, where A/Prof Mark Yates describes the interaction between dementia and these comorbidities. Earn up to 4 hours CPD. Accredited with RACGP and ACRRM.